Structural determinants of the alpha2 adrenoceptor subtype selectivity
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چکیده
منابع مشابه
Yohimbine Dimers Exhibiting Selectivity for the Human 2c-Adrenoceptor Subtype
Yohimbine is a potent and selective 2versus 1-adrenoceptor antagonist. To date, drugs with high specificity for the 2-adrenoceptor show marginal selectivity among the three 2-adrenoceptor subtypes. Initial studies showed that yohimbine was about 4and 15-fold more selective for the human 2C-adrenoceptor in comparison with the 2Aand 2B-adrenoceptors, respectively. To improve on this 2-adrenocepto...
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ژورنال
عنوان ژورنال: Journal of Molecular Graphics and Modelling
سال: 2011
ISSN: 1093-3263
DOI: 10.1016/j.jmgm.2011.04.011